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The differentiation of bone marrow mesenchymal stem cells (BMSCs) into functional nerve cells is of great significance for the treatment of neurological diseases. However, the limited neural differentiation of bone marrow mesenchymal stem cells remains a major challenge. Recent studies have shown that miRNA, as an effective signal molecule, may play a vital role in regulating the neural differentiation of stem cells. Due to their unique physical and chemical properties, miRNAs cannot be effectively delivered in vitro and in vivo, thereby inhibiting the application and translation of miRNAs.
Peng Lihua from the School of Pharmacy of Zhejiang University led the cutting-edge research of ginseng exosomes (G-Exos) as miRNA transfer vectors in the neural differentiation of bone marrow mesenchymal stem cells. The research results were published in a research article entitled "Plant exosomes as a new nanoplatform for microRNA transfer to stimulate the differentiation of neural stem cells in vitro and in vivo" in the journal Nano Letters.
In this study, the researchers isolated Exos from ginseng juice, and loaded chemokines and G-Exos onto a photocrosslinkable hydrogel to create a convenient, safe and efficient multi-purpose wound Regenerate the gel dressing to achieve targeted recruitment and induction of neural stem cell differentiation.
"This study shows that G-Exos can circumvent the limitations of traditional RNA transfer strategies, and is likely to become an effective nanoplatform for the transfer of plant-derived miRNAs to mammalian stem cells for neural differentiation in vitro and in vivo. Therefore, it has broad prospects in the nervous system. In the field of regenerative medicine," Professor Peng said. Further exploration reveals more information about the genetic mechanism behind Rett syndrome: Xue-Han Xu et al., Plant Exosomes As Novel Nanoplatforms for MicroRNA Transfer Stimulate Neural Differentiation of Stem Cells In Vitro and In Vivo, Nano Letters (2021). DOI: 10.1021/acs.nanolett.1c02530 Journal information: Nano Letters
Citation provided by Zhejiang University: Scientists identify G-Exos as a nanocarrier for miRNA transfer to stimulate neural differentiation of stem cells (October 28, 2021) Retrieved on November 18, 2021 from https://phys.org/news/2021-10- scientists -g-exos-nanocarrier-mirna-neural.html This document is protected by copyright. Except for any fair transaction for private learning or research purposes, no part may be copied without written permission. The content is for reference only.
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