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An exciting development in wound healing research has come to light, detailing a multifunctional double-layer skin patch with anti-inflammatory properties. The study was published in the journal Nanomedicine: Nanotechnology, Biology and Medicine, where researchers developed skin patches that may provide an improved, affordable and biodegradable wound dressing The solution completely changes the field of skin regeneration.
Research: A new combination of bioactive agents in a double-layer dermal patch provides excellent wound healing. Image source: Impact Photography/Shutterstock.com
Using solvent casting and electrostatic spinning technology, various wound healing agents are combined to make patches. The reported advantages include optimal wound exudate adsorption, anti-inflammatory, antioxidant and antibacterial properties.
The researchers found that the patch showed enhanced fibroblast migration and superior wound healing in rats. Fibroblasts play a key role in wound healing and help maintain the homeostasis of the extracellular matrix, which helps to re-epithelialize and restore the function of damaged tissues.
This new skin patch includes a top layer composed of polycaprolactone (PCL) and chitosan (CS), and a bottom layer composed of polyvinyl alcohol (PVA), which contains wound healing agents such as curcumin nanoparticles and Soluble eggshell membrane.
Since the skin is the largest organ of the human body, effective wound healing treatment is a constantly evolving and progressive research field.
The wound healing process includes four stages of hemostasis, inflammation, proliferation and remodeling, which can be summarized as: the formation of platelet embolism, vasodilation, and immune cell aggregation to prevent infection. Next is the growth of new granulation tissue and the formation of scars, which may take months or even years. Finally, the granulation tissue begins to mature.
Having advanced wound healing strategies will optimize this process to ensure prevention of infection, reduce inflammation and promote healing.
Wound dressings are a potential option being explored. The patch can enhance the absorption of excess wound exudate, form a microbial barrier while being non-toxic to the patient, and has the additional benefit of being degradable.
There are currently 3000 different wound healing dressings on the market to choose from; however, they do not all achieve the same healing level and must be selected according to the type of wound.
Chronic wounds may take longer to heal. Venous ulcers, pressure sores, burns and diabetic wounds are also difficult to treat. Nevertheless, it would be very beneficial to use the advanced wound care system explored in this study, which can target inflammation and provide antioxidants to the affected area.
The wound dressing proposed by the research team includes PCL, which has been approved by the FDA and is a hydrophobic biodegradable polymer that is ubiquitous in tissue engineering applications.
Due to its antibacterial and biodegradable properties, the polymer chitosan (FDA approved) is included. This combination acts as a hydrophobic layer to achieve the best water vapor transmission rate and provide a microbial barrier for advanced wound healing.
PVA is used as the hydrogel matrix. It also includes key wound healing agents and wound exudate absorbents, which are an integral part of providing a moist environment for the wound.
The wound healing agent is composed of curcumin, which is an active ingredient in turmeric. Curcumin has powerful wound healing properties, such as antioxidants, and has antibacterial and anti-inflammatory properties.
The researchers also used eggshell membranes, the thin layer between the egg white and the eggshell, which is rich in protein and provides a lot of collagen and other proteoglycans.
This layer has been used in Asian countries before and is very common; however, the low processability of this layer limits its accessibility, unfortunately, because its composition is similar to human tissue.
Animal models show that skin patches can effectively heal skin excision wounds in rats. In addition, the patch supports the production of extracellular matrix proteins for wound healing, complete wound closure, reduction of epidermal thickness, and enhancement of collagen.
Although this study has shown promising properties in terms of wound exudate adsorption and anti-inflammatory and antibacterial effects on the wound site, further large-scale in vivo studies are needed to evaluate its ability as a transformative medical product.
These studies show that curcumin and soluble eggshell membranes have exciting potential in wound healing, which may become the basis for promising new wound dressings in the future.
Continue reading: NANO-LLPO: Use nanomaterials to heal wounds.
Pillai, M., Dandia, H., Checker, R., Rokade, S., Sharma, D. and Tayalia, P., (2021) The new combination of bioactive agents in the double-layer dermal patch provides excellent wounds heal. Nanomedicine: Nanotechnology, Biology and Medicine, p.102495. Available at: https://www.sciencedirect.com/science/article/pii/S1549963421001386
Disclaimer: The views expressed here are those expressed by the author in a personal capacity, and do not necessarily represent the views of the owner and operator of this website, AZoM.com Limited T/A AZoNetwork. This disclaimer forms part of the terms and conditions of use of this website.
Marzia Khan is a lover of scientific research and innovation. She immersed herself in literature and novel therapies through her position on the Royal Free Ethics Review Board. Marzia holds a master's degree in nanotechnology and regenerative medicine and a bachelor's degree in biomedical sciences. She currently works in the NHS and participates in a scientific innovation program.
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